A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

NATURE MEDICINE（2018）

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摘要

Hyer et al . generate a potent and specific small-molecule inhibitor of the E1 ubiquitin-activating enzyme UBE1 that has antitumor activity in mice against a wide variety of tumor types.

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关键词

Chemotherapy,Drug development,Target identification,Biomedicine,general,Cancer Research,Metabolic Diseases,Infectious Diseases,Molecular Medicine,Neurosciences

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