Hepatic Smad7 overexpression causes severe iron overload in mice.

Dilay Lai,Feng Teng,Seddik Hammad,Julia Werle, Thorsten Maas,Andreas Teufel,Martina U Muckenthaler,Steven Dooley,Maja Vujić Spasić

Blood（2017）

引用 11|浏览6

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摘要

TO THE EDITOR:Most cases of genetic iron overload are characterized by elevated systemic iron levels and iron deposition in parenchymal cells due to inadequate expression of hepcidin. Here, we present a novel mouse model of iron overload due to selective overexpression of Smad7 in hepatocytes.

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