The inhibitory effect of chitosan oligosaccharides on β-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells.

Xueling Dai,Ping Chang,Xiaoxiao Li,Zhaolan Gao,Yaxuan Sun

Neuroscience Letters（2018）

引用 12|浏览8

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摘要

•COS dose-dependently decreased the cell apoptosis mediated by APPswe overexpression.•COS repressed the secretion of both Aβ40 and Aβ42 in HEK293 APPswe cells.•COS significantly reduced both BACE1 expression and enzymatic activity.•eIF2α phosphorylation was involved in COS-mediated BACE1 reduction.

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关键词

AD,BACE1,Aβ,APP,COS,MTT,HEK293 APPswe cells,PI,RP-HPLC,FRET,RT-PCR,eIF2α-P

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