Algorithm for the Automated Evaluation of NAT2 Genotypes.

Georg Michael,Ricarda Thier,Meinolf Blaszkewicz,Silvia Selinski,Klaus Golka

Methods in molecular biology (Clifton, N.J.)（2018）

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摘要

N-Acetyltransferase 2 (NAT2) genotyping by PCR and RFLP-based methods provides information on seven single nucleotide polymorphisms (SNPs) without deriving the chromosomal phase (haplotype). So genotyping results must be processed to get all possible NAT2 haplotype (or allele) combinations. Here we describe the procedure for genotyping and present a program based on Microsoft(®) Access(®) which automatically generates all possible haplotype pairs for a given unphased NAT2 genotype. NAT2 haplotypes are important to predict the NAT2 phenotype.

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关键词

Alleles,Automated evaluation,Computer program,Genotyping,Haplotype,N-Acetyltransferase 2

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