A genetically encoded tool for manipulation of NADP + /NADPH in living cells

Valentin Cracan,Denis V Titov,Hongying Shen,Zenon Grabarek,Vamsi K Mootha

NATURE CHEMICAL BIOLOGY（2017）

引用 65|浏览25

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摘要

Structure-guided engineering of an NADH oxidase switches its cofactor preference, thus yielding an NADPH oxidase that can be used to tune the cellular NADP + /NADPH ratio and to examine the links between mitochondrial NADH and NADPH pools.

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关键词

Enzymes,Metabolic pathways,Protein design,X-ray crystallography,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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