Identification of context-dependent expression quantitative trait loci in whole blood

NATURE GENETICS（2016）

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摘要

Bastiaan Heijmans, Peter ’t Hoen, Lude Franke and colleagues describe a strategy to identify context-dependent expression quantitative trait loci (eQTLs). They apply their method to peripheral blood RNA–seq data from 2,116 unrelated individuals and discover 23,060 significant cis -regulated genes, of which 12% showed context-dependent eQTL effects.

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关键词

Genome informatics,Population genetics,Gene expression

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