Disease variants alter transcription factor levels and methylation of their binding sites

Marc Jan Bonder,René Luijk,Daria V Zhernakova,Matthijs Moed,Patrick Deelen,Martijn Vermaat,Maarten van Iterson,Freerk van Dijk,Michiel van Galen,Jan Bot,Roderick C Slieker,P Mila Jhamai,Michael Verbiest,H Eka D Suchiman,Marijn Verkerk,Ruud van der Breggen,Jeroen van Rooij,Nico Lakenberg,Wibowo Arindrarto,Szymon M Kielbasa,Iris Jonkers, Peter van 't Hof,Irene Nooren,Marian Beekman,Joris Deelen,Diana van Heemst,Alexandra Zhernakova,Ettje F Tigchelaar,Morris A Swertz,Albert Hofman,André G Uitterlinden,René Pool,Jenny van Dongen,Jouke J Hottenga,Coen D A Stehouwer,Carla J H van der Kallen,Casper G Schalkwijk,Leonard H van den Berg,Erik W van Zwet,Hailiang Mei,Yang Li,Mathieu Lemire,Thomas J Hudson,P Eline Slagboom,Cisca Wijmenga,Jan H Veldink,Marleen M J van Greevenbroek,Cornelia M van Duijn, Dorret I Boomsma,Aaron Isaacs,Rick Jansen,Joyce B J van Meurs,Peter A C 't Hoen,Lude Franke,Bastiaan T Heijmans

NATURE GENETICS（2016）

引用 337|浏览11

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摘要

Peter 't Hoen, Lude Franke, Bastiaan Heijmans and colleagues present a combined analysis of methylome and transcriptome data from a large collection of whole-blood samples to infer the downstream effects of disease-associated variants. They identify a large number of trait-associated SNPs influencing methylation of CpG sites in trans , providing insights into the downstream functional effects of many disease-associated variants.

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关键词

Epigenetics,Gene regulation,Epigenomics,Gene expression

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