PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

Dai Horiuchi,Roman Camarda,Alicia Y Zhou,Christina Yau,Olga Momcilovic,Sanjeev Balakrishnan,Alexandra N Corella,Henok Eyob,Kai Kessenbrock,Devon A Lawson, Lindsey A Marsh,Brittany N Anderton,Julia Rohrberg,Ratika Kunder,Alexey V Bazarov,Paul Yaswen,Michael T McManus,Hope S Rugo,Zena Werb,Andrei Goga

NATURE MEDICINE（2016）

引用 130|浏览19

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摘要

In triple-negative breast cancer, the PIM1 kinase is highly expressed, acts to promote tumor cell survival and growth, and increases MYC transcriptional activity.

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关键词

Breast cancer,Breast cancer

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