Clonal genotype and population structure inference from single-cell tumor sequencing

Andrew Roth,Andrew McPherson,Emma Laks,Justina Biele,Damian Yap,Adrian Wan,Maia A Smith,Cydney B Nielsen,Jessica N McAlpine,Samuel Aparicio,Alexandre Bouchard-Côté,Sohrab P Shah

NATURE METHODS（2016）

引用 103|浏览14

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摘要

The open-source Single Cell Genotyper software addresses common artifacts in single-cell sequencing data in order to robustly infer clonal genotypes, enabling the study of tumor heterogeneity and evolution.

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关键词

Cancer genomics,Statistical methods,Genotype

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