IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8+ T cell-APC: a multiscale modeling study

BMC Systems Biology, Volume 10, Issue 1, 2016, Pages 77

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Keywords:
Multiscale modeling CD8+ T cells Differentiation pathway IL-2 Activation thresholdMore(1+)

Abstract:

AbstractBackgroundThe CD8+ T cell immune response fights acute infections by intracellular pathogens and, by generating an immune memory, enables immune responses against secondary infections. Activation of the CD8+ T cell immune response involves a succession of molecular events leading to modifications of CD8+ T cell population. To unde...More

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