Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity

BMC Systems Biology, Volume 10, Issue 1, 2016, Pages 16

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Keywords:
Fuzzy logic modeling Gene activity Oncogene Tumor suppressor Drug sensitivityMore(1+)

Abstract:

BackgroundHigh throughput technologies have been used to profile genes in multiple different dimensions, such as genetic variation, copy number, gene and protein expression, epigenetics, metabolomics. Computational analyses often treat these different data types as independent, leading to an explosion in the number of features making stud...More

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