Design, synthesis and preliminary biological evaluation of 4-aminopyrazole derivatives as novel and potent JAKs inhibitors.

Xuewu Liang,Yongxue Huang,Jie Zang,Qianwen Gao,Binghe Wang,Wenfang Xu,Yingjie Zhang

Bioorganic & Medicinal Chemistry（2016）

引用 9|浏览6

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摘要

•4-Aminopyrazole derivatives showed inhibitory potency against various JAKs.•The enzymatic activities of 17m were expected to reach nanomolar level.•17m could inhibit the phosphorylation of JAK2 in Hela cells effectively.

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关键词

Inhibitors,JAKs,Kinase,4-Aminopyrazole

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