Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

Yanyan Gao,Xiufeng Bai,Dejiu Zhang,Chunsheng Han,Jing Yuan,Wenbin Liu,Xintao Cao,Zilei Chen,Fugen Shangguan,Zhenyuan Zhu,Fei Gao,Yan Qin

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

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摘要

Genetic ablation of EF4 in mice leads to male sterility due to mitochondrial translation defects, which can be compensated for in somatic tissues by mTOR-mediated upregulation of cytoplasmic translation.

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关键词

Mitochondria,Translation

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