Collagenase Clostridium histolyticum: emerging practice patterns and treatment advances.

OBJECTIVE:This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). METHODS:This review is based on a literature review and practical experience. RESULTS:This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. CONCLUSION:CCH has an evolving role as one of the tools available for treating Dupuytren's disease.