An efficient and simple methodology for the synthesis of 2-amino-4-( N -alkyl/arylamino)-6-chloropyrimidines

Tetrahedron Letters（2015）

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摘要

(a) NaOMe, MeOH, reflux, (b) POCl3, N,N-dimethylaniline, 60°C, (c) Et3N, H2NR/Ar, fusion.

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关键词

2-Amino-4,6-dichloropyrimidine,Dimethylmalonate,Guanidine hydrochloride,Heterocycles,Nucleophilic substitution

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