The inhibitory role of Co2+ on α-glucosidase: Inhibition kinetics and molecular dynamics simulation integration study

•The inhibitory effect of Co2+ on alpha-glucosidase: binding mechanisms and the responsive residues of alpha-glucosidase.•Research methods via integrating between inhibition kinetics and computational simulations.•The supportive data from MD simulations for the dynamic action of Co2+ on the inhibition of alpha-glucosidase.•The potent therapeutic action for treating type 2 diabetes mellitus of Co2+.