Ultrastructural observation on hepatocellular carcinoma
Medical Molecular Morphology(1993)
摘要
In 31 cases of hepatocellular carcinoma, electron microscopic observation and morphometry on the cell organelles were carried
out to evaluate the usefulness of electron microscopy for the diagnosis of well differentiated hepatocellular carcinoma. The
cell organelles in well differentiated tumor cells were very similar to those in normal hepatocytes or hepatocytes with liver
cirrhosis (LC). We found that in poorly differentiated tumor cells, the nuclear area, N/C ratio, nucleolar area, the amount
of dispersed chromatin, and the number of free ribosomes had increased, but the cellular area, degree of nuclear roundness,
and mitochondrial area had decreased. These results seem to indicate that electron microscopy is not as useful as light microscopy
in the diagnosis of well differentiated hepatocellular carcinoma, but is useful in the study of poorly differentiated tumor
cells, which indicated that the cell proliferation through mitoses was activated.
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关键词
tumor grade,ultrastructure,cell organelles,morphometry,hepatocellular carcinoma,electron microscopy,cell proliferation,electron microscope,light microscopy
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