RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression.

Jie Qiu,Wenwei Zhang,Qingsheng Xia,Fuxue Liu, Li Li,Shuwei Zhao, Xian Gao,Chuanshan Zang,Ruifeng Ge,Yan Sun

Experimental and Molecular Pathology（2016）

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摘要

•A set of 936 differentially expressed genes (DEGs) was identified.•RRM2 were the hub node in protein-protein interaction (PPI) network and module 3.•Several collagens were both the hub nodes in PPI network and module 5.•ECM degradation and cell cycle pathways were pronounced for the DEGs.•PLAU, PSG1 and EGR2 had higher transcriptional activity in PTC than control.

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关键词

Papillary thyroid carcinoma,RNA-sequencing,Differentially expressed genes,Enrichment analysis,ECM degradation,Cell cycle

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