A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells.

A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO-.