Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

Xintian You,Irena Vlatkovic, Ana Babic,Tristan Will,Irina Epstein,Georgi Tushev,Güney Akbalik,Mantian Wang,Caspar Glock,Claudia Quedenau,Xi Wang,Jingyi Hou, Hongyu Liu,Wei Sun,Sivakumar Sambandan,Tao Chen,Erin M Schuman,Wei Chen

NATURE NEUROSCIENCE（2015）

引用 913|浏览25

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摘要

The authors discovered that circular RNAs are significantly enriched in the mouse brain and can be visualized in situ , near synapses. They observed that many circRNAs change their abundance during synaptogenesis and also following neuronal homeostatic plasticity, suggesting a function for circRNA in regulating synaptic development and plasticity.

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关键词

RNA,Synaptic development,Synaptic plasticity,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics

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