Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
NATURE(2014)
摘要
metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibition of succinate accumulation ameliorates ischaemia-reperfusion injury in a mouse model of heart attack and a rat model of stroke.
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关键词
Metabolomics
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