Inositol phosphosphingolipid phospholipase C1 regulates plasma membrane ATPase (Pma1) stability in Cryptococcus neoformans.

Amir M Farnoud,Visesato Mor,Ashutosh Singh,Maurizio Del Poeta

FEBS Letters（2014）

引用 26|浏览7

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摘要

•The role of Isc1 on Pma1 transport and stability in C. neoformans was studied.•Isc1 deletion does not inhibit Pma1 synthesis or its transport to the plasma membrane.•Pma1 oligomerization is inhibited in the absence of Isc1.•Addition of phytoceramide restores Pma1 oligomerization.

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关键词

Plasma membrane,Inositiol phosphosphingolipid phospholipase C (Isc1),Plasma membrane ATPase (Pma1),Sphingolipid,Cryptococcus neoformans

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