HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

Graham A Heap,Michael N Weedon,Claire M Bewshea,Abhey Singh,Mian Chen,Jack B Satchwell,Julian P Vivian,Kenji So,Patrick C Dubois,Jane M Andrews,Vito Annese,Peter Bampton,Martin Barnardo,Sally Bell, Andy Cole,Susan J Connor,Tom Creed,Fraser R Cummings,Mauro D'Amato,Tawfique K Daneshmend,Richard N Fedorak,Timothy H Florin,Daniel R Gaya,Emma Greig,Jonas Halfvarson, Alisa Hart,Peter M Irving,Gareth Jones,Amir Karban,Ian C Lawrance,James C Lee,Charlie Lees,Raffi Lev-Tzion, James O Lindsay,John Mansfield,Joel Mawdsley,Zia Mazhar,Miles Parkes,Kirstie Parnell,Timothy R Orchard,Graham Radford-Smith,Richard K Russell, David Reffitt,Jack Satsangi,Mark S Silverberg,Giacomo C Sturniolo,Mark Tremelling,Epameinondas V Tsianos,David A van Heel,Alissa Walsh, Gill Watermeyer,Rinse K Weersma,Sebastian Zeissig,Jamie Rossjohn,Arthur L Holden,Tariq Ahmad

NATURE GENETICS（2014）

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摘要

Graham Heap, Tariq Ahmad and colleagues show that common variants in the HLA-DQA1–HLA-DRB1 region confer susceptibility to thiopurine-induced pancreatitis in individuals undergoing treatment for inflammatory bowel diseases. These findings could help identify patients at risk of developing this serious adverse reaction to thiopurine therapy.

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关键词

hypersensitivity,complication,genome wide association,genome wide association studies,genetics,population,drug therapy,therapy,genotype,medical genetics

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