Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
NATURE(2014)
摘要
Using a new method to estimate DNA methylation turnover rate, embryonic stem cells are shown to lack clonal transmission of methylation but still maintain a stable epigenetic state, whereas somatic cells transmit methylation clonally but lose epigenetic state coherence owing to the persistence of accumulated methylation errors.
更多查看译文
关键词
DNA methylation, Epigenetic memory
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要