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排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
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(11)C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor

Ian M Bell,Steven N Gallicchio,Craig A Stump,Joseph G Bruno,Hong Fan,Liza T Gantert,Eric D Hostetler,Amanda L Kemmerer,Melody McWherter,Eric L Moore,Scott D Mosser,Mona L Purcell,Kerry Riffel,Christopher A Salvatore,Sandra Sanabria-Bohórquez,Donnette D Staas,Rebecca B White,Mangay Williams,C Blair Zartman,Jacquelynn J Cook,Richard J Hargreaves,Stefanie A Kane,Samuel L Graham,Harold G Selnick

ACS medicinal chemistry letters（2013）

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摘要
Rational modification of the potent calcitonin gene-related peptide (CGRP) receptor antagonist MK-3207 led to a series of analogues with enhanced CNS penetrance and a convenient chemical handle for introduction of a radiolabel. A number of (11)C-tracers were synthesized and evaluated in vivo, leading to the identification of [(11)C]8 ([(11)C]MK-4232), the first positron emission tomography tracer for the CGRP receptor.
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关键词
mk-4232,calcitonin gene-related peptide receptor,positron emission tomography,biomedical research,text mining,bioinformatics
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