Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme.

Beata Wielgus-Kutrowska,Anna Modrak-Wójcik,Alicja Dyzma,Katarzyna Breer,Michal Zolkiewski,Agnieszka Bzowska

Archives of Biochemistry and Biophysics（2014）

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摘要

•The decline of calf PNP activity with time correlates with the decrease in concentration of the trimeric species.•During aging, calf PNP forms large aggregates while isolated monomers are not detected.•Phosphate stabilizes the enzyme and delays the aging process.•Data suggests that calf PNP is an obligate trimer.

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关键词

Analytical ultracentrifugation,Protein stability,Protein association,Oligomeric proteins,Differential scanning calorimetry,Circular dichroism

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