The influence of epsilon-aminocaproic acid on the mineralocorticoid hypertension of the rat.

The development of hypertension induced by DOCA/salt in rats can be reduced by epsilon-aminocaproic acid. Analogously to the clinical finding, glomerulopathy is also less marked. Recognising on the one hand the interaction between the coagulation system and the vessel wall and on the other hand the fibrinolysis-blocking properties of EACA, it can be assumed that derangements of the coagulation system are aetiologically involved in hypertension induced by salt/DOCA. As a secondary finding, it was observed that the course of an existing lung infection is deleteriously affected by fibrinolysis-blockade with EACA.