Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils.

Lidija Radenovic,Vesna Selakovic,Sara Olivan,Ana Cristina Calvo,Amaya Rando,Branka Janac,Rosario Osta

Brain Research Bulletin（2014）

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摘要

•The effect of tetanus toxin C (TTC) fragment was tested in ischemic gerbils.•TTC improved the neurological status and survival of ischemic gerbils.•TTC completely abolished ischemia-induced oxidative stress in the brain of gerbils.•TTC decreased ischemia-induced motor hyperactivity of gerbils.

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关键词

Global ischemia,Motor behavior,Neuroprotection,Oxidative stress,TTC

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