Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.

Bioorganic & Medicinal Chemistry Letters（2012）

引用 14|浏览37

暂无评分

摘要

Two highly selective sub–series of DFG-out leads for PYK2, an indole-urea and a pyrazole-urea were identified, and found to bind with different interactions in the hinge region of PYK2.

查看译文

关键词

PYK2,FAK,DFG-out,Osteoporosis,Kinase inhibitor,BIRB-796

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要