A complex gene regulatory mechanism that operates at the nexus of multiple RNA processing decisions

David S McPheeters,Nicole Cremona,Sham Sunder,Huei-Mei Chen,Nicole Averbeck,Janet Leatherwood,Jo Ann Wise

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2009）

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摘要

Meiosis is a highly conserved and tightly regulated process in which one round of DNA synthesis is followed by two rounds of division. By studying the expression of crs1 pre-mRNA, a meiotic cyclin in fission yeast, Wise and co-workers found that increased RNA accumulation during meiosis is not due to an increase in transcription but rather is a result of RNA processing and turnover. Moreover, they found that polyadenylation of crs1 is linked to splicing, a coupling previously thought to occur only in mammals. They suggest that this highly integrated crs1 regulatory system may allow a rapid response to adverse conditions.

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关键词

apoptosis,transcription,rnai,translation,molecular,exosomes,dna recombination,signal transduction,rna processing,chromatin structure,dna replication,macromolecules,nucleic acids,cell cycle,protein folding,rna,dna repair,molecular biology,biophysics,chromatin remodeling,chromatin,mechanism,gene expression,cell biology,cyclins,biochemistry,proteins,rna splicing,genetics

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