Synthesis, characterization, crystal structure and cytotoxicities of 2-aroyl-3-aryl-5H-furo[3,2-g]chromene derivatives

Five 2-aroyl-3-aryl-5H-furo[3,2-g]chromene derivatives have been synthesized, and their structures were characterized by IR, NMR, ESI-MS and elemental analysis. The crystal structure for 2-benzoyl-3-(4-methoxyphenyl)-6,7-dihydro-5H-furo[3,2-g] chromene has been determined by single-crystal X-ray diffraction. X-ray analysis reveals that the pyran ring adopts a half-chair conformation, while the fused furo[3,2-g] chromene ring is approximately coplanar with a slight distortion. The preliminary pharmacological test showed all target compounds exhibit cytotoxicities against the U2OS-EGFP-4F12G cell line.