Role of phospholipids and copolymers in enhancing stability and controlling degradation of intravenous lipid emulsions

•Emulsifier mixture can alter the emulsion activation energy and stability.•Emulsions prepared with the emulsifier mixture have low degradation rate.•Emulsifiers with high transition temperature and steric hindrance enhance stability of oil droplets.•Insight on the rational design of submicron emulsions for intravenous administration.