Synthesis and in vitro cytotoxic activity evaluation of novel heterocycle bridged carbothioamide type isosteviol derivatives as antitumor agents.

Song-Lin Zhu,Ya Wu,Cong-Jun Liu,Chang-Yong Wei,Jing-Chao Tao,Hong-Min Liu

Bioorganic & Medicinal Chemistry Letters（2013）

引用 26|浏览7

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摘要

Two series of novel carbothioamide-substituted pyrazole and isoxazolidine derivatives were facilely prepared. Within all compounds, 12p (IC50=6.51μM) showed the highest cytotoxic activity against Raji cell.

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关键词

Isosteviol,Pyrazole,Isoxazolidine,Cytotoxicity

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