Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.

JOURNAL OF MEDICINAL CHEMISTRY（2009）

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摘要

The Synthesis and characterization of a novel polycyclic azaindole based derivative is disclosed, and its binding to JAK2 is described. The compound is further evaluated for its ability to block the EPO/JAK2 signaling cascade in vitro and in vivo.

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