Solid-phase synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and β-amino acids
Tetrahedron Letters(2001)
摘要
We report here the synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and β-amino acids using a backbone amide linker (BAL) as a cis-configuration inductor. We have optimized each steps of the synthesis on solid support using Mimotopes crowns.
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关键词
diazepine,mimotopes crowns,backbone amide linker
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