Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles

Caroline M. Reid,Charles Ebikeme,Michael P. Barrett,Eva-Maria Patzewitz,Sylke Müller,David J. Robins,Andrew Sutherland

Bioorganic & Medicinal Chemistry Letters（2008）

引用 24|浏览29

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摘要

A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes have been synthesized and shown to have significant in vivo anti-protozoal activity against both trypanosome and malaria parasites.

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关键词

Macrocycles,Anti-protozoal,Trypanosomes,Malaria

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