A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285.

Francis Gosselin,Stephen Lau,Christian Nadeau,Thao Trinh,Paul D O'Shea,Ian W Davies

JOURNAL OF ORGANIC CHEMISTRY（2009）

引用 33|浏览16

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摘要

A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proximity-induced anionic cyclization, followed by imidazole synthesis and late-stage cyanation.

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