ChemInform Abstract: Synthesis and Structure-Activity Relationship of (Lactamylvinyl) cephalosporins Exhibiting Activity Against Staphylococci, Pneumococci, and Enterococci.

I. HEINZE-KRAUSS,P. ANGEHRN,P. GUERRY,P. HEBEISEN,C. HUBSCHWERLEN,I. KOMPIS,M. G. P. PAGE,H. G. F. RICHTER, V. RUNTZ, H. STALDER, U. WEISS,C.-C. WEI

Cheminform（2010）

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摘要

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue (1) are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.

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关键词

structure activity relationship,antibiotics

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