Promoter methylation correlates with reduced NDRG2 expression in advanced colon tumour
BMC medical genomics(2009)
摘要
Aberrant DNA methylation of CpG islands of cancer-related genes is among the earliest and most frequent alterations in cancerogenesis and might be of value for either diagnosing cancer or evaluating recurrent disease. This mechanism usually leads to inactivation of tumour-suppressor genes. We have designed the current study to validate our previous microarray data and to identify novel hypermethylated gene promoters.
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关键词
Colon Cancer Cell Line,NDRG2 Expression,BMDP Statistical Software,Bisulfite Sequencing Analysis,NDRG2 Gene
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