The response of uterine fibroids to GnRH-agonist treatment can be predicted in most cases after one month

Twenty-seven patients with uterine fibroids were treated for 3 months with the GnRH-agonist goserelin prior to surgical myomectomy. Ovarian function was suppressed reliably in all patients. After three applications, 15 fibroids were reduced in volume by more than 50%, and one complete remission was achieved. Seven patients showed a decrease of 10–50% in volume. However, in 5 cases there was no significant reduction.