Taguchi design experiments for optimizing the gas chromatographic analysis of residual solvents in bulk pharmaceuticals

Taguchi design experiments were conducted in order to identify and optimize the parameters that yield a maximum separation of 26 solvents commonly found in bulk pharmaceuticals. Wide-bore columns with chemically cross-linked stationary phases of different polarities were retained owing to their sensitivity and specificity in optimizing the analysis via a simple response function based on information theory.