Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities.

Chunyang Jin,G Manikumar,John A Kepler,C Edgar Cook,George F Allan,Margaret Kiddoe,Sheela Bhattacharjee,Olivia Linton,Scott G Lundeen,Zhihua Sui

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been synthesized and evaluated for their antiprogesterone and antiglucocorticoid activities.

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关键词

Steroidal spiro-oxazole,Progesterone receptor,Glucocorticoid receptor,Antagonist,Selective progesterone receptor modulators

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