Molecular and cellular characterization of urinary bladder-type aquaporin in Xenopus laevis.
General and Comparative Endocrinology(2015)
摘要
•We first identified urinary bladder-type AQPa2, AQP-x2, in the aquatic anurans.•AQP-x2 was localized to the cytoplasm of granular cells in the urinary bladder.•10−8M AVT and 10−6M hydrins failed to translocate AQP-x2 to the apical membrane.•10−6M AVT partially induced translocation of AQP-x2 to the apical membrane.•This poor response of AQP-x2 is important for water homeostasis in aquatic anurans.
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关键词
Aquaporin,AQP-x2,Urinary bladder-type AQPa2,Vasotocin,Hydrins,Xenopus laevis
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