Co-Administration Of Sr141716 With Peptide Yy3-36 Or Oxyntomodulin Has Additive Effects On Food Intake In Mice

Background: SR141716 has been shown to significantly inhibit food intake and reduce body weight by antagonizing CB1 receptors. The gut hormones peptide YY3-36 (PYY3-36) and oxyntomodulin (OXM) inhibit food intake through Y-2 and Glucagon-Like-Peptide (GLP)-1 receptors respectively.Objective: To determine the effects of co-administration of SR141716 with either PYY3-36 or OXM in mice on food intake.Methods: Mice (n = 14 per group) were fasted for 16 h prior to study days and given two intraperitoneal injections: study 1, vehicle-saline, SR141716-saline, vehicle-PYY3-36 or SR141716-PYY3-36; study 2: vehicle-saline, SR141716-saline, vehicle-OXM or SR141716-OXM.Food was returned and measured following injections.Results: Co-administration of SR141716-PYY3-36 or SR141716-OXM showed greater inhibition in food intake when compared with administration of SR141716, PYY3-36 or OXM alone.Conclusion: Our data show that SR141716 in combination with PYY3-36 or OXM reduces food intake additively in mice.