Influence of BM 12.531 (Prop. INN azimexon) on the lymphocyte transformation and the percentage of active T lymphocytes in vivo and in vitro in man
Cancer Immunology Immunotherapy(1979)
摘要
Patients with different types of cancer received treatment PO or IV with the new immunostimulating compound, 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, BM 12.531 (Prop. INN azimexon). After IV administration of 200 mg on 5 consecutive days or oral administration of 300 mg on 7 consecutive days a significant increase in the percentage of active T lymphocytes was seen. After in vitro incubation of different concentrations of BM 12.531 with blood from healthy donors there was a significant increase in the percentage of active T lymphocytes. No clear influence of BM 12.531 on the lymphocyte transformation caused by various concentrations of PHA could demonstrated because of the scatter.
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关键词
Clinical Trial, Propane, Cancer Research, Oral Administration, Healthy Donor
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