Combination of replenishing qi to nourish yin method,eliminating blood stasis method with chemotherapy in the treatment of multi-drug resistant pulmonary tuberculosis: A randomized controlled trial

Objective To evaluate the clinical efficacy and safety of combined replenishing qi to nourish yin methods,eliminating blood stasis methods with chemotherapy in the treatment of multi-drug resistant pulmonary tuberculosis.Methods Seventy-two cases were randomized into treatment group and control group by 1:1 randomized parallel controlled trial.All cases in both of the groups were treated by chemotherapy,and the cases in treatment group were added Chinese granular formulation for pulmonary tuberculosis,with the course of 18 months.The sputum smear,culture negative conversion rate,focus absorption of chest X-ray,cavity closure rate,symptom score,and quality of life were observed.Results ①At the end of the treatment,there were statistical differences in grade count of sputum specimens between before and after treatment in both of the groups(P0.05,P0.01);the the sputum smear and culture negative conversion rate of acid-fast bacilli were 73.5% and 56.2% in treatment group and control group respectively,with a significant difference between the two groups(P0.05).②The effective rate of chest X-ray was 73.5% in treatment group and 53.1% in control group,and the cavity closure rate was 80.6% in treatment group and 53.5% in control group,with a significant difference between the two groups(P0.05).③The overall effective rate of Chinese medicine was 100.0% in treatment group and 65.6% in control group,with a difference between the two groups(P0.05).④In treatment group,there were significant differences in body function,psychological health,society function,body pain,total health and total living accumulated points between before and after treatment(P0.01);in control group,there were significant differences in body function,total health and total living accumulated points between before and after treatment(P0.01).After treatment,there were significant differences in body pain,psychological health,total health and total living accumulated points between the two groups(P0.05,P0.01).Conclusion Combined replenishing qi to nourish yin method,eliminating blood stasis method with chemotherapy can improve the negative conversion rate of sputum,promote focus absorption and cavity closure,and improve the quality of life in patients with pulmonary tuberculosis.