Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

C Asker,C Mareni,D Coviello,S Ingvarsson,M Sessarego,P Origone,G Klein,J Sumeigi

Leukemia Research（1988）

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摘要

Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10–15 fold amplified c-myc sequences. The linked pvt-l-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

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关键词

c-myc,amplification,leukemia

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