基本信息
浏览量:178
职业迁徙
个人简介
We have been working on various aspects of developmental neurobiology, from neurogenesis, asymmetric cell division and more recently to neuronal morphogenesis and repairmen by using Drosophila. Initially, we focused on how neuronal cell fates are specified. In 1993, we discovered Atonal, which turns out to be the founding member of an important family of proneural genes including Neurogenin, Math 1 and Math 5. We also discovered the role of the homeodomain protein Cut in specifying subtypes of neurons. These studies provided insights to neuronal cell fate specification.
We next addressed the question of how do two daughters of a neural progenitor acquire different cell fates. We approached this problem by studying Drosophila sensory bristle, which is derived from a single precursor that goes through 4 divisions giving rise to 5 cells. Each division is asymmetric. We identified numb mutant, in which all the divisions become symmetrical. In 1994, we discovered that Numb is asymmetrically localized to one pole of the precursor cell and segregated into one of the daughter cells to make them different. This process is repeated in all the divisions of the sensory bristle linage as well as in the neuroblast divisions. Numb is the first cell fate determinant identified for asymmetric cell division in the nervous system. Subsequent studies by us and the others, concerning how Numb and other cell fate determinants are localized to one of the two daughter cells to specify their fates, have provided insights about the mechanisms of asymmetric cell division, a basic mechanism for generating cell diversity.
In the past 16 years, dendrite morphogenesis has become the main focus of our lab. Dendrites are part of neuron used to receive signal. They are among the most beautiful structures in biology. Each type of neuron has distinct dendritic morphology. So dendrite morphology is a distinguishing hallmark of a neuron. Not much was known about the underlying mechanisms when we started studying this problem in 1999. We found that the dendritic arborization (da) neurons of the Drosophila larval PNS are very well suited for studying dendrite morphogenesis. Those neurons could be divided into 4 different classes based on their dendritic morphology. By using them, my colleagues and I have gained some insights about dendrite development. For example: how neurons with distinctive dendrite morphologies depend on their level of Cut expression for diverse dendrite branching complexities, how certain types of neurons exhibit homotypic repulsion of their dendrites to allow tiling of the dendritic field for maximal coverage without ambiguity, by revealing the essential role of the NDR family kinase Tricornered, how tiling and dendrite maintenance can be differentially regulated by the upstream NDR family kinase and tumor suppressor Hippo, and how a differential reliance on the secretory pathway contributes to the differentiation of axons and dendrites. More recently, by taking advantage of the wealth of information gained from our study of normal dendrite morphogenesis, we have begun to study the molecular mechanisms controlling the regeneration of axons and dendrites after injury.
研究兴趣
论文共 569 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
NATURE STRUCTURAL & MOLECULAR BIOLOGYno. 4 (2024): 580-581
Kai Li,Yanmeng Guo, Yayu Wang,Ruijun Zhu,Wei Chen,Tong Cheng, Xiaofan Zhang,Yinjun Jia,Ting Liu,Wei Zhang,Lily Yeh Jan,Yuh Nung Jan
Nature Cell Biologyno. 3 (2024): 393-403
bioRxiv : the preprint server for biology (2023)
Ruijun Zhu,Yuh Nung Jan
Nature cell biologyno. 4 (2023): 518-519
Shengjie Feng,Cristina Puchades,Juyeon Ko,Hao Wu, Yifei Chen,Eric E Figueroa,Shuo Gu,Tina W Han, Brandon Ho,Tong Cheng,Junrui Li,Brian Shoichet,
Nature communicationsno. 1 (2023): 4874-4874
John P. Adelman,David E. Clapham,Hiroshi Hibino,Atsushi Inanobe,Yuh Nung Jan, Andreas Karschin,Yoshihiro Kubo,Yoshihisa Kurachi, Michel Lazdunski,Takashi Miki,Colin G. Nichols,Lawrence G. Palmer,
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
引用0浏览0引用
0
0
Jungwoo Wren Kim, Adeline J. H. Yong,Ted M. Dawson,Valina L. Dawson,Yuh-Nung Jan,Nicholas T. Ingolia
biorxiv(2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn