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职业迁徙
个人简介
My academic research focused on three areas: cell cycle control, cancer metabolism and the ubiquitin-proteosome system (UPS). In the study of cell cycle control, my research pursuits have led to the discovery of the first mammalian G1 cyclin-dependent kinases (CDKs), the D-type cyclins and its catalytic subunit, CDK4, the first CDK inhibitor, p21, and three additional CDK inhibitor genes. My research also demonstrated the alteration of CDK complexes by oncogenic transformation, the INK4-CDK4-RB pathway, and the regulation of p53 by the tumor suppressor ARF and ribosomal proteins. These discoveries helped to establish the framework of G1 control. My research in cancer metabolism led to the discovery of acetylation regulation of a large number of metabolic enzymes and metabolite regulation of multiple epigenetic enzymes. My research on the UPS focuses on the cullin-RING family E3 ubiquitin ligases (CRLs). This research has led to the discovery of the catalytic subunits (ROC1 and ROC2), assembly mechanisms for CRL3 and CRL4, a key regulator (CAND1) of the CRLs and multiple disease-linked CRL substrates. These findings helped to establish CRLs as the largest family of E3 ligases (estimated to be ~300) which regulate many cellular processes. They also provided the insights for exploiting the UPS, CRL in particular, for targeted protein degradation in drug discovery. I have published more than 200 peer-reviewed research articles and invited reviews (total citations: >50,000; h-index: 102).
研究兴趣
论文共 296 篇作者统计合作学者相似作者
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Colton J Treadway, Joshua A Boyer, Shiyue Yang,Hui Yang,Mengxi Liu,Zhijun Li,Meng Cheng,William F Marzluff,Dan Ye,Yue Xiong,Albert S Baldwin,Qi Zhang,
ACS chemical biology (2024)
Daniel Horn-Ghetko,Linus V. M. Hopf, Ishita Tripathi-Giesgen, Jiale Du,Sebastian Kostrhon, D. Tung Vu,Viola Beier,Barbara Steigenberger,J. Rajan Prabu, Luca Stier, Elias M. Bruss,Matthias Mann,
Nature Structural & Molecular Biology (2024)
Daniel Horn-Ghetko,Linus V. M. Hopf, Ishita Tripathi-Giesgen, Jiale Du,Sebastian Kostrhon, D. Tung Vu,Viola Beier,Barbara Steigenberger,J. Rajan Prabu, Luca Stier, Elias M. Bruss,Matthias Mann,
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2024)
Daniel Horn-Ghetko,Linus V. M. Hopf, Ishita Tripathi-Giesgen, Jiale Du, Sebastian Kostrhon, D. Tung Vu, Viola Beier, Barbara Steigenberger, J. Rajan Prabu, Luca Stier, Elias M. Bruss, Matthias Mann,
Daniel Horn-Ghetko,Linus V M Hopf, Ishita Tripathi-Giesgen, Jiale Du,Sebastian Kostrhon, D Tung Vu,Viola Beier,Barbara Steigenberger,J Rajan Prabu, Luca Stier, Elias M Bruss, Matthias Mann,
Nature structural & molecular biology (2024)
The Journal of clinical investigationno. 6 (2023)
Leukemiano. 8 (2023): 1764-1765
Matthew R. Ramsey,Janakiraman Krishnamurthy,Xin-Hai Pei,Chad Torrice, Weili Lin, Daniel R. Carrasco,Keith L. Ligon,Yue Xiong,Norman E. Sharpless
crossref(2023)
crossref(2023)
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