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He and his research team established new collaborations with fellow SMHS research faculty to successfully compete for the award of a Program Project Grant from the NHLBI that concentrated on: free radical mechanisms of cardiovascular injury, the antioxidant properties of beta blocker and othe cardiovascular drugs, and the role of magnesium deficiency in causing cardiomyopathy;importantly, the cause of this latter cardiovascular pathology was soon discovered to be due to neurogenic inflammation, due to the hypomagnesemia-related release of substance P from sensory nerves, that triggered production of excessive systemic free radical injury. This finding was confirmed by the use of NK1-receptor blocking agents that significantly protected cardiac and other tissue injury due to substance P. Our more recent Research Interests (below), focusing on anticancer drug toxicity/side effects, identified the significant protection by aprepitant (Emend),a clinically used NK1- blocking antinausea drug, against the impairment of cardiac ventricular dysfunction and cutaneous lesions caused by aprepitant (Tarceva), a tyrosine kinase inhibitor used to treat lung cancer.
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Journal of Dermatology and Skin Scienceno. 1 (2024): 1-8
Isolated Adult Cardiomyocytespp.145-161, (2019)
HIV/AIDS: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS (2018)
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